• Catalytic Domain - Degrades oligosaccharides from the non-reducing end releasing glucose.
• Starch-Binding Domain - Binds the enzyme to raw starch and to the cell wall.
• Linker - Extended rod connecting the two domains.

Information:

• Active-Site Interaction with Maltose in Aspergillus niger
• Chemical Modification and Site-Directed Mutagenesis of Aspergillus niger Glucoamylase (Old File)
• Glucoamylase Sequences divided by Sub-Families
• Glucoamylase Structure: Insight for Protein Engineering - a small text on our current research.
• Variability of 1gly residues following Multisequence Alignment
• Structural and Functional Analysis of the Starch Hydrolysing Enzyme Glucoamylase - A Ph.D. Dissertation by Bjarne Stoffer
• Automated Docking of  -(1,4)- and -(1,6)-Linked Glucosyl Trisaccharides in the Glucoamylase Active Site - Our recent poster presented at the 2nd Electronic Molecular Graphics and Modelling Conference

Reference Material:

• BLOCKS Entry at Fred Hutchinson Cancer Research Center (W3)
• EC Enzyme Entry (w/ SwissProt Links) at Expasy, Switzerland (W3)
• LIGAND Entry (w/ PIR and PDB Links) at GenomeNet, Japan (W3)
• LITDB Search at GenomeNet, Japan (W3)
• Papers and Patents (more than 1200 w/ Abstracts) collected at Stack-Serpukhov, Russia (W3)
• PMD Search at GenomeNet, Japan (W3)
• PROSITE Entry (w/ SwissProt Links) at ExPASy, Switzerland. (W3)
• SBASE Search (/w Several Links) at ICGEB-Trieste, Italy (W3)
• SCOP Search (/w PDB Links) at Cambridge, UK (W3)

Last Changed: 97/10/08