Developmental Biology ONLINE!

Mitosis

This page features a series of photographs of whitefish blastula cells in the various stages of mitosis. Use the "Forward" and "Backward" buttons to navigate through the full cycle of phases shown. You can either skip straight to the whitefish blastula cell slides or you can view a diagram of mitosis* as an orientation. At the bottom of the page, there are a few links to sites which explain mitosis and may be able to help you if you are still confused.


Diagrammatic Mitosis*

This diagrammatic representation of mitosis shows the cell undergoing a full cycle of division to produce two daughter cells.

Diagramatic Mitosis
* This image taken from: http://www.gene.com/ae/AB/GG/mitosis1.html

To the first slide!
Keep watching the cows!

Interphase Mitosis - Interphase

This cell is shown, as this is how all cells look before mitosis. Please be aware that Interphase is a phase of the cell cycle, but NOT a stage of mitosis.

Forward Backward First slide (Interphase) Diagrammatic mitosis


Early Prophase Mitosis - Early Prophase

To begin mitosis, the nuclear membrane breaks down, while the chromosomes shorten and thicken (here, a chromosome is two chromatids, bound at a point called the centromere, making an "X" shape). The other structures important for mitosis are also forming (i.e. the centrioles).

Forward Backward First slide (Interphase) Diagrammatic mitosis


Metaphase Mitosis - Metaphase

The mitotic spindle apparatus has now formed and lies on the poles of the nucleus (but remember, the nuclear membrane has broken down, so there is no distinctly delineated nucleus). The chromosomes are lined up along the cell's equator, also known as the equatorial plate, and are attached to the mitotic spindle apparatus via microtubules (to try and visualize the microtubules extending from the poles to the chromosomes on the equator, think of the Earth - it's as if rope was extending from the chilly north and south poles to the chromosomes basking in the sun at the equator). Here's the confusing part - When the individual chromatids (½ of the "X") are separated from the chromosome (the "X"), they are now each referred to as a chromosome (i.e. In metaphase, the chromosome, composed of two chromatids, separates into the individual chromatids, which are then renamed chromosomes, even though they were only one half of a chromosome only moments before!) - Whew!

Forward Backward First slide (Interphase) Diagrammatic mitosis


Anaphase Mitosis - Anaphase

The newly formed chromosomes (which were recently chromatids while they were still ½ of the "X") are pulled along the microtubules toward opposite poles of the cell (like Monarch butterflies migrating back to Canada and the southern tip of South America (toward the poles) from Mexico (near the equator).

Forward Backward First slide (Interphase) Diagrammatic mitosis


Telophase Mitosis - Telophase

The chromosome have finished their migration to the poles and the mitotic structures breakdown. The plasma membrane of the cell pinches down along the equator creating two separate cells (similar to twisting a long balloon and forcing it to pinch in the middle). At this time, the chromosomes become indistinct (as they are during Interphase), the nuclear membrane forms again and the nucleolus reappears.

Forward Backward First slide (Interphase) Diagrammatic mitosis

Keep watching the cows!

Some Other Sites Explaining Mitosis


This page is part of the Developmental Biology ONLINE! web site.
Special thanks to Hans Christoffersen for the preparation of this page.

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Send comments to:

Dr. Steven Scadding ( scadding@uoguelph.ca ) or Sandra Frombach (sfrombac@uoguelph.ca),

Department of Zoology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

Last Revision: August 10, 1998